The star was at the premiere for her latest film Planetarium, and according to reports she's pregnant with her second child.
The Hollywood star, known for her roles in blockbusters such as Black Swan and Thor, looked a vision in white while she posed for photographers and fans.
Appearing in Venice to promote her new film, it wasn't just the star's beauty that had onlookers talking, as a baby bump could be seen in her flowing white dress.
Natalie wore a white, floor-length Dior gown that skimmed her figure and clung to her stomach, showing off her baby bump.
Natalie herself has not confirmed her pregnancy as of yet, but several sources have confirmed the happy news to US Weekly and E!News.
This new baby will be Natalie's second child, joining her five-year-old son Aleph who she shares with her French husband Benjamin.
Natalie met Benjamin while filming Black Swan in 2009 and the pair dated for three years before marrying in 2011.
The couple tied the knot in a Jewish ceremony before moving to Paris.
When Benjamin became the Paris Opera Ballet's director of dance, the entire family moved to France, though Natalie has spoken out about struggling with the change of culture before.
Although Natalie was born in Israeli she describes herself as a Los Angeles native through and through, and moved back to the States earlier this year. Talking about her love for living in LA during an appearance on the Jimmy Kimmel Live TV show, Natalie said 'Everyone smiles a lot here. It's so nice. They're more cool in France. I didn't realise I got used to it until I got here and I was so surprised.'
Natalie has been open about enjoying parenthood, telling The Telegraph she 'loves being a mum'.