The stunning star appeared alongside Esther Rantzen and Chris Hoy to chat to Matt Baker and Alex Jones about her work with Childline, after it was revealed that Cheryl will be the new face of the charity.
The star also spoke candidly about the downfalls of fame, likening it to how many teens can feel scrutinized and under pressure in their own lives before admitting that she experienced depression when she was younger.
Childline, which was founded by Dame Esther Rantzen in 1986, marks its 30th anniversary this week. The charity hopes that with Cheryl fronting the campaign, more children will come forward to seek help when they need it.
Image: The One Show/BBC
Cheryl spoke about her work with Childline alongside Esther Rantzen and Chris Hoy
'I was actually quite a depressed teenager... just the pressure of going home and your parents wanting you to do well in your exams', Cheryl said.
'Your hormones play a huge part in your teenage years of how you feel. I wouldn't go back to my teenage years for love nor money.'
In a statement earlier this week, the star said: 'As a teenager I was aware of Childline, but like so many others I mistakenly thought it was just for young kids.
'The reality is that it doesn't matter whether you are at primary, secondary school or college, or how big or small your problem is, Childline is there for you.'
Cheryl with her boyfriend, One Direction star Liam Payne
Cheryl is never far from media speculation, and she addressed any unwanted attention on the show, saying she's become 'thick-skinned' now, before joking: 'Come at me bro!'.
'You come to an age where you've got through it, you've grown from those experiences, you learn, you become you, you're comfortable in your own skin.
'You just think go away, I honestly couldn't give a...' before she tailed off laughing.
Image: The One Show/BBC
The star looked happy and relaxed as she chatted with Matt and Alex
The former X Factor judge went on to address her own personal experiences that aren't often seen by the public. 'There was a period of time where I was going through really really hard personal stuff, and being chased around at the same time by seven strangers and seven cars every day, relentlessly and I found that extremely difficult to deal with.
'Then you've got the scrutiny, the lies, all the stuff on social media. That's how I can relate to the kids too because I've experienced the judgement, the bullying if you like, because to an extent it is.'