Rather than wait until Madge finishes touring, the pair are believed to be about to release a statement to formally confirm the split.
Recent rows are said to have escalated because although Guy, 40, loves adopted son David Banda, 3, he does not want to have more kids.
‘Guy adores David and is glad they went ahead with the adoption,’ says a source. ‘But he doesn’t want to adopt another child when their marriage is rocky. It’s a real bone of contention. Everyone agrees it is unfair on the children to witness such terrible arguments and so the divorce has been agreed.’
The relationship is said to be so strained that Madonna, 50, and Guy have been communicating only through their aides.
‘Guy has been the one who has come to the conclusion that enough is enough,' the source tells the Daily Mail. 'They had planned to make it work in the New Year...but it quickly became clear that the relationship was not worth saving.'
Madonna is also mum to Lourdes, 12, with ex Carlos Leon, and Rocco, 8, with Guy.
The film director is expected to move out of the marital home in Marylebone, London, and into his Wiltshire mansion.
Madonna's publicist has said there will be an announcement when America wakes up. Watch this space...
In other lighter news, check out Madonna's ridiculous shoes from the other night! The heels are mini guns. What on earth is all that about?