Charlie Slater (Derek Martin), Minty (Cliff Parisi), Liz Turner (Kate Williams), Danny Mitchell (Liam Bergin), Libby Fox (Belinda Owusu) and Adam Best (David Proud) will leave the Square later this year.
Details of their exits, masterminded by new executive producer Bryan Kirkwood, are secret.
'It's sad to see characters leave the Square,' says a BBC spokeswoman.
'But obviously when a new executive producer comes on board they're always keen to refresh the show and make some changes.
'It's the way soaps work, characters run their course and new characters come along.'
Where to next?
- Best EastEnders moments
- Celebrity picture quiz
- Latest celeb gossip