Other causes of cirrhosis?
Less common causes include:
- Chronic infection with the hepatitis B virus. World-wide this is the most common cause of cirrhosis (but alcohol and hepatitis C are the most common causes in the UK).
- Autoimmune hepatitis. The immune system normally makes antibodies to attack bacteria, viruses, and other germs. In people with autoimmune diseases, the immune system makes antibodies against part(s) of the body. Something triggers the immune system to make these auto-antibodies. (The trigger is not known.) In autoimmune hepatitis the immune system makes antibodies against liver cells which can lead to damage and cirrhosis.
- Diseases that cause blockage of the bile ducts can cause back pressure and damage to the liver cells. For example, primary biliary cirrhosis, sclerosing cholangitis, and congenital problems of the bile ducts.
- Nonalcoholic steatohepatitis (NASH). This is a condition which causes fat to build up in the liver. This can lead to scarring and cirrhosis.
- Severe reactions to certain drugs.
- Certain poisons and environmental toxins.
- Certain infections caused by bacteria and parasites which are usually found only in tropical countries.
- Repeated bouts of heart failure which can cause back pressure of blood and congestion in the liver.
- Some rare inherited diseases which can cause damage to liver cells. For example:
- Haemochromatosis. This is a condition which causes an abnormal build up of iron in the liver and other parts of the body.
- Wilson's disease. This is a condition which causes an abnormal build up of copper in the liver and other parts of the body.
- Other rare disorders.
Where to next?
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Other causes of cirrhosis?
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What are the symptoms of cirrhosis?
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What is the outlook?
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What is the treatment for cirrhosis?
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Alcohol and liver disease
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'No alcohol for under-15s' says government
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Primary biliary cirrhosis
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What are bile and bile ducts?
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What are the symptoms of PBC?
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What causes PBC?
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What does the liver do?


