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What causes cancer? Part 2

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Each cancer is thought to first start from one abnormal cell. What seems to happen is that certain vital genes which control how cells divide and multiply are damaged or altered. This makes the cell abnormal. If the abnormal cell survives it may multiply 'out of control' into a malignant tumour.

We all have a risk of developing cancer. Many cancers seem to develop for no apparent reason. However, certain risk-factors are known to increase the chance that one or more of your cells will become abnormal and lead to cancer. Risk factors include the following:

Chemical carcinogens

A carcinogen is something (chemical, radiation, etc) which can damage a cell and make it more likely to turn into a cancerous cell. As a general rule, the more the exposure to a carcinogen, the greater the risk. A list of known and suspected chemical carcinogens can be found at http://physchem.ox.ac.uk/MSDS/carcinogens.html

Well-known examples include:

  • Tobacco smoke. If you smoke, you are more likely to develop cancer of the lung, mouth, throat, oesophagus, bladder and pancreas. Smoking is thought to cause about a quarter of all cancers. About 1 in 10 smokers die from lung cancer. The heavier you smoke, the greater the risk. If you stop smoking, your risk goes down considerably.
  • Workplace chemicals such as asbestos, benzene, formaldehyde, etc. If you have worked with these without protection you have an increased risk of developing certain cancers. For example, a cancer called mesothelioma is linked to past exposure to asbestos.

Age

The older you become, the more likely that you will develop a cancer. This is probably due to an accumulation of damage to cells in the body over time. Also, the body's defences and resistance against abnormal cells may become less good as you become older. For example, the ability to repair damaged cells, and the immune system which may destroy abnormal cells, may become less efficient with age. So, eventually one damaged cell may manage to survive and multiply 'out of control' into a cancer. Most cancers develop in older people.

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