Mike Brandon was first diagnosed with Acute Lymphoblastic Leukemia (ALL) in January 2014, just a month after he proposed to Kate.
After a campaign urging people to sign up onto the donor registry that went viral, Mike found a match and had a life saving stem cell transplant on 26th June 2014, the day of his 30th birthday.
Kate has also released a video asking for help
The following year Mike and Kate tied the knot, and his health continued to improve, until recently.
Just before Easter weekend, Mike received the terrible news that his leukaemia had returned and this time it was spreading even more aggressively.
Now the only option for treatment is a trial treatment of CAR T-Cell Therapy, with researchers at the University of Pennsylvania's Abramson Cancer Centre, USA.
The treatment is funded by the University, but Mike still needs to fund the medical costs associated with its administration, which is thought to be at least £400,000.
Kate is now urging people to help her save her husband's life by donating via her Donate4Mike GoFundMe page.
In the appeal, she wrote: 'We cannot do this without your help, which is why I am here again to ask you to share our page, spread the word and donate whatever you can to help me save the life of the most wonderful man I have ever met.'
Thanks to the generosity of the over 17,000 people who've been touched by their story, Kate has managed to fundraise £344,185 in eight days, leaving her a £56,000 away from their goal.
If you'd like to help Mike and Kate, please visit their Donate4Mike GoFundMe page in the link above.