As Wednesday's show ended, the Scottish presenter, 46, said that it would be her last show for a while because of medical issues.
‘Just to let you know, don't worry if you don't see me for the next month or so,' she said. ‘I am actually going to be off at home convalescing.
‘I'm having a hysterectomy tomorrow...lots of personal reasons for that. I did go to the doctor's and talk about it.'
Hysterectomies are a surgical procedure in which the womb is removed, meaning that the patient will be unable to conceive from that point forwards.
Although Andrea said she was undergoing the procedure for 'medical reasons', the most common reasons for hysterectomies range from treating heavy periods, long-term pelvic pain, non-cancerous tumours, and the more serious concerns like ovarian, uterine or cervical cancer.
Andrea was visibly upset, as she broke the news. Immediately, her co-hosts as well as the audience showed their support saying she'll be 'alright', with Saira Khan jumping up to give her a reassuring hug.
Image:Loose Women/ITV Studios
Andrea is a mum to 14-year-old Finlay with her first husband, BBC producer Nick Green, and nine-year-old Amy with second husband Steve Toms.
She's been open in the past about her health, speaking out about her fight against post-natal depression.
She spoke in an episode earlier this year about how she was 'gripped' by it, saying 'I had postnatal depression for two years before I finally went to the doctors. It's something I suffered from and hid.
'Now what's really interesting is we're all really talkative women and I've been working on this show for nine years now and I had it while I was on this show.
'A lot of people obviously see me and I've been in hair and make-up and I'm all professional and I do my job smiling, interacting, being interested and engaged but what I was doing was literally sobbing all the way home.'
Andrea finished Wednesday's episode with a teary wave, saying 'I will be at home watching you guys but that's where I will be just in case you are wondering.'
Since then, she's been tweeting about her time away so far.
I'm overwhelmed by your lovely comments about my op tomorrow - if I was emotional before you've ruined me! Thank you so much xx— Andrea McLean (@andrea_mclean) September 21, 2016
We wish her the best of luck with the operation, and a speedy recovery!